IGNOU MFN-02
- Nutritional Biochemistry,
Latest Solved Assignment
(July 2023 - January 2024)

Section A –Descriptive Questions
There are ten questions in this part. Answer all questions.
1. a) What is starch? Give its biochemical structure.
b) List the important reactions of monosaccharides. Explain any two in detail.
c) Give an example of a Trisaccharide.What is it made up of?

2. a)What are Eicosonoids? Briefly describe their role in the body.
b) Discuss the four basic structural levels of proteins, giving examples.

3. a) List the different classes of enzymes. Explain any two in detail.
b) Explain briefly the three major classes of enzyme inhibition?
c) Name the enzymes whose blood levels are determined during clinical diagnosis of nephrotic syndrome.

4. a) Describe the role of enzymes in digestion of food in the body.
b) Explain the process of absorption and transport of lipids in our body.

5. a) What is gluconeogenesis? Discuss the four substrates used in gluconeogenesis.
b) What is Phosphogluconate pathway? Give any three significance of this pathway.

6. a) Write briefly the steps involved in cholesterol synthesis in the body.
b) What do you understand by the term hyperproteinemias.
c) Name three ketone bodies seen in ketosis.

7. a) Explain the Urea cycle indicating the enzymes and co-enzymes involved in it.
b) Explain the different ways by which non essential amino acid is biosynthesised .

8. a) Describe the role of free radicals in lipid peroxidation.
b) What are antioxidants? Give their classification and role in brief.

9. a) Indicate the steps involved in formation of vitamin D3.
b) Why minerals are essential for us? Give the biochemical role of zinc in our body.

10. a) What do you understand by the term “inborn errors of metabolism”?
b) Differentiate between Group I and Group II hormones, giving examples.

Section B - OTQ (Objective Type Questions)
1. Explain the following in 2-3 sentences. Also give the structure wherever possible.
a. Isomer
b. Essential fatty acids
c. Isoprene
d. Turnover number
e. Brush border
f. Electron Transport Chain
g. Ketosis
h. Metalloflavoproteins
i. Transcription
j. Allosteric mechanisms

2. Name the defective enzyme in the following diseases:
a) Alcaptonuria
b) Gaucher’s disease
c) Homocystinuria
d) Pentosuria
e) Albinism

3. Match the items in List I with items in List II :
List I                                              List II
I Maltose                                        A Glucose + Maltose
II Type IV hyperproteinemia     B Glucose + Glucose
III Sucrose                                     C Glucose + Galactose
IV Type II a hyperproteinemia  D Glucose + Fructose
V Lactose                                        E Increase cholesterol +Triglyceride
F Increase cholesterol +LDL
G Increase cholesterol +Triglyceride+VLDL

Section A –Descriptive Questions

There are eight questions in this part. Answer all questions.

1. a) Define isomers. Explain stereo isomerism and optical isomerism of monosaccharides in detail.
b) List any two chemical properties of the following:
i) Fatty acids
ii) Proteins

2. a)Define protein and its monomeric unit. Give classification of amino acid with the structural formula.
b) Briefly describe physio chemical properties of fat-soluble vitamin.

3. a) Define enzyme and coenzyme. Explain models for mechanism of enzyme action in detail with diagram.
b) What are essential fatty acids? Name any two essential fatty acids and their food sources.

4. a) Explain urea cycle.
b) Explain ß-oxidation of fatty acid with diagram.

5. a) What is the role of pancreas in digestion of food? Explain.
b) How does the HMP pathway differ from glycolysis? Discuss the metabolic significance of HMP pathway in detail.

6. a) Work out the energy (ATP) production when glucose is oxidized in the Glycolysis and citric acid cycle pathways. (Illustrate the cycle and work out the ATP production)
b) What are free radicals and antioxidants? Give examples of each.

7. a) Explain the following:
(i) Role of Vitamin A in the visual cycle.
(ii) Role of Vitamin D in the intestinal absorption of calcium in our body.
b) What is inborn error of metabolism? Enlist the disease related to carbohydrate metabolism and explain any one.

8. a) Describe the biochemical role of the hormones produced by the following glands in our body:
(i) Adrenal Medulla
(ii) Anterior Pituitary
b) Differentiate between the following disease conditions:
i)Maple Syrup Urine Disease and Alcaptonuria
ii) Thalassemia and Sickle cell anaemia

Section B - OTQ (Objective Type Questions)

1. Explain the following in 2-3 sentences. Also give the structure wherever possible.

a. Amylopectin
b. Galactosemia
c. Dehydrogenation
d. Porphyrins
e. Apolipoproteins
f. Thromboxanes
g. Anaplerotic reaction
h. Isozymes
i. Mutarotation
j. Zwitterion

2. Name the defective enzyme in the following diseases:

a) Phenylketonuria
b) Tyrosinemia Type I
c) Niemann-Pick disease
d) Hereditary Lactose intolerance
e) Pentosuria

3. Match the following:

I Porphyrin                   A 3-hydroxybutyrate
II Ketone bodies          B Heme
III Lipoprotein             C Glutathione peroxidase
IV Lactate                     D HDL
V Selenium                   E Cori Cycle