IGNOU MVE-03
- Pharmaceutics,
Latest Solved Assignment
(January 2024 - July 2024)

Answer all the questions given below.
1. Briefly explain the different kinds of dosage forms.

2. What are the various methods used for sterilization of pharmaceutical products. Discuss any one of them briefly.

3. a) Briefly describe any three tests carried out for the evaluation of the parenteral products
b) Explain the following:
i) Slow first order release system
ii) Slow zero order release

4. a) What is Pharmacokinetics?
b) What are the factors which affect biotransformation of drugs? Discuss briefly.
c) What is first pass effect?

5. Describe briefly the four Phases of Clinical trials.

6. a) Explain any two of the following
i) Bioavailability
ii) Excipient
iii) Nuremberg code
b) Discuss briefly the factors affecting bioavailability?

7. a) Write short note on monoclonal antibodies.
b) Describe various mechanism for gastrointestinal absorption.

8. Write the composition of the following:
i) Oil Shampoo
ii) Henna rinse
iii) Face powder (any one)
iv) Toothpaste
v) Mouth wash

9. a) What is difference between phytochemicals and nutrients? Give the sources of the following phytochemicals.
i) Allyl sulfides
ii) Indoles
iii) Isoflovnes
iv) Lignans
v) Flavonoides
b) Write note on “Uses of Radiopharmaceuticals”

10. a) What are different types of probiotics? Discuss them briefly.
b) Discuss the therapeutic uses of probiotics.

Q.1 a) What is a dosage? Calculate the dose of a drug for a one year old and an 11 year old child, if the adult dose is 500 mg.
b) What are Liquid dosage forms? Give their advantages and disadvantages.

Q.2 a) Explain the following terms in 1-2 lines:

i) Elixirs
ii) Enemas
iii) Collodions
iv) Douches
v) Suppositories

b) What do you understand by the term Sterilization? Describe any one method of sterilization.

Q.3 a) What are parenterals? Describe its different routes of administration.
b) What are the different forms of Ointments? Discuss each of them briefly in your own words.

Q.4 a) Describe the various types of gastro-intestinal devices.

b) Explain the following terms in 1-2 lines:

i) CDDS
ii) Transdermal
iii) Negative Contrast Media
iv) Electromagnetic radiation
v) Bioequivalence

Q.5 a) Fill in the following blanks:

i) ---------------- diffusion describes the movement of drug from region of high concentration to lower.
ii) --------------- indicates a measurement of rate and extent of the active drug delivered to general circulation.
iii) The diet tends to decrease the acidity of gastric fluid to a pH of about --------------
iv) --------------- is a measure of drug elimination from body without reference to the mechanism of process.
v) Physical absorption by invagination of cell membrane is known as ------------------

b) What are the pharmaceutical factors which affect on absorption of drugs? Discuss each of them briefly.

Q.6 Give the importance of the following in 3-4 lines only.

i) Controlled Trial
ii) Nuremberg Code
iii) Antioxidants
iv) Biopharmaceutics
v) Open Trial

Q.7 a) Fill in the following blanks:

i) __________is defined as a hybrid cell produced by the fusion of an antibody-producing lymphocyte with a__________ cell and used to culture continuously a specific monoclonal antibody.
ii) _________ molecules can be fragmented by passing their suspension through a syringe needle.
iii) _________enzyme catalyses the formation of phosphodiester bond between base pairs.
iv) Mabs are immunoglobulins of a single species derived from the cloned _________, its fused derivatives or transformants.

b) What do you understand by monoclonal antibodies? Explain briefly.

Q.8 Give the uses of the followings

i) Sunscreen cream
ii) Vitamin cream
iii) Hair grooming aids
iv) Mouth gargle
v) Massage cream

Q. 9 a) What are Phytochemicals? Explain with suitable examples.
b) Discuss ingredients of Nutraceuticals briefly.

10. a) Explain the following terms in few lines

i) Composition of face powder
ii) Composition of aftershave lotion
iii) Bifidobacteria

b) What are the proposed therapeutic uses of probiotics?